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The Multidimensional Prognostic Index (MPI) for the Prognostic Stratification of Older Inpatients with Covid-19: A Prospective Observational Trial

Status: Planned (Transit Ethics), pub.

Purpose / Objectives

Primary Outcome

To evaluate if the MPI can predict in Covid-19 older inpatient

  1. the admission to ICU
  2. In-hospital mortality


Secondary Outcomes

To assess after 3-months whether the MPI predicts

  1. the length of stay
  2. rehospitalization
  3. admission in long-term care facility
  4. mortality



Patient attributes

Inclusion criteria

  • Patients ≥ 65 years of age
  • Consecutively admitted to the hospital with ascertained diagnosis of COVID-19 through swab with RT-PCR
  • Willing to participate to the study

Exclusion criteria

  • Age < 65 years
  • Unwilling/unable to participate to the study

Trial design

  • Prospective


At baseline, after signing informed consent, all recruited patients will undergo data collection for the calculation of the CGA-based MPI including ADL and IADL, SPMSQ, MNA-SF, Exton-Smith score, number of drugs taken, comorbidities and cohabitation status.


In addition, discharge destination, therapy plan at admission and discharge, length of hospital stay, main diagnosis and other diagnoses, will be collected. Moreover clinical, biological and radiological parameters regarding COVID-19 infection will be collected at baseline and at hospital discharge.


After 3 months from discharge, patients and/or caregivers will be contacted to collect information about survival and rehospitalizations.


Documents (password protected)

Responsibilities in overall trial

National Coordinating Investigator

Prof. Dr. Dr. Maria Cristina Polidori Nelles