Recapture 2

1. Patient must provide a signed written informed consent prior to any study-specific procedures.

2. Patient must be 18 to 90 years of age, inclusive.

3. Patient has a clinically suspected and/or bacteriologically documented cUTI or acute pyelonephritis judged by the investigator to be serious (requires patient to be hospitalized for treatment with IV therapy).

4. Female patient is authorized to participate in this clinical study

5. Female patient is authorized to participate in this clinical study if at least one of the following criteria are met. Surgical sterilization, (eg, bilateral oophorectomy and/or bilateral salpingectomy,but excluding bilateral tubal occlusion)

1. A Gram stain demonstrates that a Gram-positive organism is present, or if urine culture results are available, demonstrates Gram-positive organisms are present at ≥105 CFU/mL.

2. Where a urine culture result is available, at least 1 Gram-negative uropathogen is resistant to CAZ-AVI or doripenem.

3. Where a urine culture result is available, patient’s urine culture at study entry isolates more than 2 microorganisms regardless of the colony count.

4. Where a urine culture result is available, patient has a confirmed fungal UTI with colony count >103 CFU/mL.

5. Patient has received any prior antibiotic before the initiation of study therapy for this infection.

Avibactam vs. Doripenem